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Harvard biologist George Church burst into the headlines (yet again) last week when he helped organize a closed-door meeting of scores of top scientists to discuss accelerating efforts to create synthetic DNA — including a complete human genome. They’re considering launching a decade-long drive to build, from scratch, all the genes that make humans human.

In recent months, Church has been vocal in saying that the much-hyped genome-editing technology called CRISPR4, which is only a few years old and which he helped develop, would soon be obsolete. Instead of changing existing genomes through CRISPR, Church has said, scientists could build exactly the genomes they want from scratch, by stringing together off-the-shelf DNA letters.

The topic is a heavy one, touching on fundamental philosophical questions of meaning and being. If we can build a synthetic genome — and eventually, a creature — from the ground up, then what does it mean to be human?

Vanderbilt University Medical Center nephrologist and Associate Professor of Medicine Dr. William H. Fissell IV, is making major progress on a first-of-its kind device to free kidney patients from dialysis. He is building an implantable artificial kidney with microchip filters and living kidney cells that will be powered by a patient’s own heart.

“We are creating a bio-hybrid device that can mimic a kidney to remove enough waste products, salt and water to keep a patient off dialysis,” said Fissell. Fissell says the goal is to make it small enough, roughly the size of a soda can, to be implanted inside a patient’s body.

April 24, 2018

Synthetic Biology

GLP Archives for Synthetic Biology

Synthetic biology is an emerging field focused on engineering new biological systems that do not already exist in Nature or redesigning existing systems from scratch. Scientists are working to build new life forms, assembling them from their fundamental chemical components. They are trying to use biotechnology to produce substances that are difficult to obtain by other means—medicines and fuels, in particular. Because synthetic biology brings together so many disciplines, some have hailed it as the genesis of the next Industrial Revolution.